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what type of cell signaling is clonal selection?

Answers

Answer 1

The clonal selection theory proposes that antigen selects lymphocytes for activation from a population of cells precommitted to produce specific antibody. Implicit in this theory is that antibody-forming cells are monospecific and express cell-surface receptors capable of binding foreign antigens.

Interaction of antigen with these side chains induced the cell to synthesize additional antibody molecules. This proposal seemed untenable once Karl Landsteiner demonstrated that the immune system could produce antibodies to a vast array of antigens; for over 50 years theories of antibody formation postulated that antigen instructed cells to synthesize antibodies complementary to the antigen. The introduction of the clonal selection theory of antibody formation by Macfarlane Burnet in the 1950s revived the idea that antibody-forming cells express cell-surface receptors by which they bind antigen. In 1961, Göran Möller provided the first evidence that antibody-forming cells had antibody (immunoglobulin) on their surface. The antigenbinding specificity of these immunoglobulin molecules was shown to be identical to the antibody that cells will produce when activated. Initially, many immunologists thought that the T lymphocyte receptor would also be an immunoglobulin molecule. However, studies by several laboratories in the early 1980s using a combination of monoclonal antibodies and molecular genetic techniques showed that the receptor consists of two polypeptide chains. The antigen-specific receptors on both T and B lymphocytes are associated with other trans-membrane molecules involved in the transduction of activation signals into the cell.

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Answer 2

Answer:

the clonal selection theory proposes that antigen selects lymphocytes for activation from a population of cells precommitted to produce specific antibody. Implicit in this theory is that antibody-forming cells are monospecific and express cell-surface receptors capable of binding foreign antigens.

For example, memory B cells that differentiate after an adaptive immune response are thought to undergo clonal selection so that antibodies produced by newer memory B cells have considerably higher binding affinities to their antigens. And it is a receptor

Explanation:


Related Questions

Describe If each statement describes England, or Spain, France and Russia.

Parliament had important powers.

Monarchs had limits on their power

Absolutism was increasing

Monarchs grew more powerful

Answers

Answer:

Look at the screenshot below.

Have a great day

Explanation:

Thank-you letters should be sent out within
of the interview.
O A. one week
B. one day
C. one month
D. a few days

Answers

Answer:

B. one day

Explanation:

It's best to send a thank you letter while you're still fresh in the interviewer's mind. So you should send the email message within 24 hours of the interview (the same day as the interview or the next).

Hereditary spherocytosis (HS) is a disorder of red blood cells that causes the cells to be smaller and spherical instead of having the usual flattened, biconcave shape. The average diameter of normal red blood cells is 7.2μm, and the average diameter of red blood cells in a person with HS was found to be 6.7μm. The normal red blood cell has an average surface area of 136μm2 and an average volume of 91μm3.

Which of the following provides an accurate calculation of the surface area to volume ratio of an HS red blood cell, as well as a prediction of its effect on the efficient transferring of oxygen compared to a normal red blood cell?

Answers

The statement that provides an accurate calculation of the surface area to volume ratio of an HS red blood cell is The ratio is 0.89, and the cells are less efficient at transferring oxygen.

The ratio 0.89 is less than the ratio that is seen in a normal red blood cell, therefore, the cell would be less organized at moving oxygen.

Hereditary spherocytosis (HS) is often referred to as a disease that can be inherited. It is known to affects the red blood cells.

Its symptoms includes the killing of red blood cells in the spleen and their removal from the blood stream amidst others.

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Hereditary spherocytosis (HS) is a disorder of red blood cells that causes the cells to be smaller and spherical instead of having the usual flattened, biconcave shape. The average diameter of normal red blood cells is 7.2μm, and the average diameter of red blood cells in a person with HS was found to be 6.7μm. The normal red blood cell has an average surface area of 136μm2 and an average volume of 91μm3.

Which of the following provides an accurate calculation of the surface area to volume ratio of an HS red blood cell, as well as a prediction of its effect on the efficient transferring of oxygen compared to a normal red blood cell?

A  The ratio is 0.45, and the cells are more efficient at transferring oxygen.

B  The ratio is 1.12, and the cells are less efficient at transferring oxygen.

C  The ratio is 0.89, and the cells are less efficient at transferring oxygen.

D  The ratio is 141, and the cells are more efficient at transferring oxygen.

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When you use a match to light a candle, multiple _______ of energy occur

Answers

Answer:

transformations (missing word)

Explanation:

When you use a match to light a candle, multiple transformations of energy occur.

To light a match, mechanical energy must first be converted to thermal energy. The particles in the match release chemical energy that has been accumulated as a result of the thermal energy, which then transforms into further thermal energy and the electromagnetic energy that you see as light.

Multiple energy transformations involving mechanical, thermal, chemical, and light energy occur when you light a match.

Therefore, when you use a match to light a candle, multiple transformations of energy occur.

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What is the quantity of books that this individual is carrying in the image provided.

Answers

Answer:

3

Hope it helps

Is it bad to love someone even after you have broken up?

Answers

-Answer: no, not at all

Answer:

Nope :)

Explanation:

I don't believe so. The heart wants what the heart wants. If you truly love that other person and not for body features then there is no shame. After all, you broke up with the other person for a reason and you already broke ties with. Do consider it might come off as if you move on too quickly but other than it's not really bad.

compare relative motion and relative velocity

Answers

The difference between velocity and relative velocity is that velocity is measured with respect to a reference point which is relative to a different point. While relative velocity is measured in a frame where an object is either at rest or moving with respect to the absolute frame

Your sister is looking for a way to increase the amount of money she is earning in her savings account what should she do

Answers

Answer:

a good why to make some rly good money on the side id to either sell the items u don't need nor use and also as well u can be a photographer and sell pics online or take some creative pictures for people its super easy and simple.

Assume that a 100 cm3 soil core weighs 78g when oven-dried and 123 g when saturated. Calculate the total pore space and total porosity. Show all of you work.

Answers

To calculate the total pore space, we will find the difference between the mass of the soil when it is oven - dried and when it is saturated. Therefore, the value of the total pore space and total porosity are 45g and 45% respectively

Given that a 100 cm3 soil core weighs 78g when oven-dried and 123 g when saturated.

The given parameters are;

Volume of soil V = 100[tex]cm^{3}[/tex]

Mass ( Oven dried) [tex]M_{1}[/tex] = 78g

Mass ( Saturated) [tex]M_{2}[/tex] = 123g

In the soil formation, pore space refers to the volume of soil. And to calculate the total pore space, we will find the difference between the mass of the soil when it is oven - dried and when it is saturated. That is,

Total pore space =  [tex]M_{2}[/tex] - [tex]M_{1}[/tex]

Total pore space = 123 - 78

Total pore space = 45g

And total porosity will be the percentage of the ratio of total pore space to the given volume of the soil. That is,

Total porosity = (Total pore space / volume of the soil) x 100

Total porosity = 45/100 x 100

Total porosity = 0.45 x 100

Total porosity = 45%

Therefore, the value of the total pore space and total porosity are 45g and 45% respectively

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sunog na nagsulong sa pagtatag ng pamahalaang sibil sa pilipinas


(G O S U S N O P O S E R)


pasagutan po agad

Thank you po​

Answers

Answer: Susog spooner

who greets the speaker and the speakers friends

Answers

Answer:

In the poem "The Blessing" By James Wright

Explanation:the internet

2. Thomas wants to add a watermark to his spreadsheet and chooses a giant black plus sign.
Assuming his spreadsheet is full of enough data to cover several pages and uses plain
styling with no filling, what issue will Thomas run into? What could Thomas possibly
do to use something similar as a watermark?

Answers

Answer:

An issue Thomas might run into is..

Explanation:

Thomas might run into the issue that people will not be able to see the data.

Thomas could make the watermark a lighter color such as a light gray or even a light blue instead of black and Thomas could add filling to his styling to make it easier to see and read.

WILL MARK BRAINLIEST IF WORK IS SHOWN


Mr. Jackson's dog Gromit jumped out of a second story window (through the screen) and fell to the ground below. The window is 15 feet high, the acceleration of gravity is 9.8m/s2, and there are 3.28 feet in each meter. What was the final velocity of this crazed dog?

Answers

Answer:

calculate with formula plz

if you had one person to save in 5 sec who would it be.

Answers

Keanu Reeves :3

hes a national treasure

từ vẻ đẹp của Vũ Nương trong đoạn trích ở phần đọc - hiểu, viết đoạn văn ( khoảng 20 câu ) về những việc làm thể hiện lòng hiếu thảo của em với cha mẹ.

Answers

what is that mean about that

What type of population distribution pattern is exhibited by a flock of birds that nest close together?

Answers

Answer:

A clumped population

Explanation:

Mostly they were observed in flocks which firmly indicated that their distribution pattern is clumped.

❤❤goodmorning everyone, today is going to be an amazing day dont let anyone bring you down today! remember to love your self!!!❤

Answers

Answer:

Ok thank u!

Explanation:

How are you doing today?

Answers

Answer:

great

Explanation:

Answer:

im doing ok

Explanation:

Ive had to to a lot of homework and cleaning today but hopefully it pays off :)

(NEED ASAP)


Type the correct answer in each box.

In the figure, lines m and n are parallel to each other. Lines pand are also parallel to each other. 68°.

The value of x is[-------] degrees, and the value of y is [-------] degrees.​

Answers

[tex]\Large \boxed{\sf y=68, x=112}[/tex]

A transversal line cuts two parallel lines, producing pairs of angles with unique features.

    y. Corresponding angles are equal (68=68)

    x. Angles on a straight line add up to 180 degrees (180-68=112)

What were Austria’s aims and priorities at the congress

Answers

Answer: to reestablish peace and stability in Europe

Explanation:  The goal of the conservatives at the Congress, led by Prince Klemens von Metternich of Austria, was to reestablish peace and stability in Europe. To accomplish this, a new balance of power had to be established.

Which of the following is an example of Balkanization? Please Help!!!

Answers

Answer:

Yugoslavia

Explanation:

The former Yugoslavia has become five independent countries and the province of Kosovo is currently fighting to break away of what is left of Yugoslavia.

Answer:

Balkanization. The term comes from the Balkan Peninsula of Europe, a region that has balkanized may time, and is still undergoing balkanization. EXAMPLES: The former Yugoslavia has become five independent countries and the province of Kosovo is currently fighting to break away of what is left of Yugoslavia.

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¿Cuál personaje desempeña el rol del "gracioso" o "donaire" en el fragmento?

Answers

Que fragmento no lo veo pero em no se -

in the second paragraph, the question with which the narrator confronts her mother (“i took....my dad”) reveals which of the following about there contrasting values?

Answers

Answer:

Matilda's anger is tempered by her mother's sense of humor. Her mother's leniency is at odds with Matilda's more objective point of view.

Explanation:

What did anthropologists William and Jean O'Barr find in examining the factors that influence a
person's style of speech when testifying as a witness in court?

Answers

Answer:

Social influences somehow interfered with normal, biologically based behavior patterns to produce same-sex attraction.

Explanation:

Search What did anthropologists William and Jean O'Barr find in examining the factors that influence a

person's style of speech when testifying as a witness in court?

Psychological tools are used to understand human behavior and psychological processes

Answers

case studies ,surveys ,naturalistic observation , and laboratory observation are examples of descriptive or correlational researches methods . using these methods researchers can describe different events ,experiences,or behaviours and look for links between them

Psychologists study mental processes and human behavior by observing, interpreting, and recording how people and other animals relate to one another and the environment. ... Research methods vary with the topic which they study, but by and large, the chief techniques used are observation, assessment, and experimentation.

-

Mga Batayang Salik sa pagkakaroon ng pagkakaroon ng kabihasnan
1
2
3
4
5
6

pls I need your help

Answers

Explanation:

Matatag na suplay ng pagkain.

Sosyal na istraktura.

Sistema ng pamahalaan.

Sistemang panrelihiyon.

Mataas na binuo na kultura.

Mga pag-unlad sa teknolohiya.

Mataas na binuo nakasulat na wika.

Insecure but I'm working with it
Many things that I could get rid of
Ain't about to give it up
I made a few mistakes, I regret it nightly
I broke a couple hearts that I wear on my sleeve
My mama always said, girl, you're trouble
And now I wonder, could you fall for a woman like me
And every time we touch, boy, you make me feel weak
I can tell you're shy and I think you're so sweet
Spending every night under covers and
Still I wonder, how could you fall for a woman like me (A woman)

Answers

Answer:

its called women like me

Explanation:

i looked it up

COS(α+β); SINα=- 1/3, α IN QUADRANT IV, TANβ=7/3, β IN QUADRANT III

Answers

Recall the angle sum identity for cosine,

cos(α + β) = cos(α) cos(β) - sin(α) sin(β)

We're given sin(α) = -1/3 and tan(β) = 7/3. Since α terminates in quadrant IV, we know that cos(α) is positive, and since β terminates in quadrant III, both sin(β) and cos(β) are negative.

Recall the Pythagorean identities,

cos²(x) + sin²(x) = 1

and

1 + tan²(x) = sec²(x)

Using the first identity, we find

cos²(α) = 1 - sin²(α)

cos(α) = + √(1 - (-1/3)²)

cos(α) = + √(8/9)

cos(α) = √8/3

Using the second identity,

sec²(β) = 1 + tan²(β)

sec(β) = - √(1 + tan²(β))

sec(β) = - √(1 + (7/3)²)

sec(β) = - √(58/9)

sec(β) = -√58/3

cos(β) = -3/√58

Then by definition of tangent,

tan(β) = sin(β) / cos(β)

sin(β) = tan(β) cos(β)

sin(β) = (7/3) (-3/√58)

sin(β) = -7/√58

Putting everything together,

cos(α + β) = cos(α) cos(β) - sin(α) sin(β)

cos(α + β) = (√8/3) (-3/√58) - (-1/3) (-7/√58)

cos(α + β) = -(7 + 3√8)/(3√58)

What does it mean to be ‘other oriented’?

Answers

Answer:

The process of acting on information. What does it mean to be other -oriented? To be aware of the thoughts, needs, experiences, personality, emotions, motives, desires, culture, and goals of your communication partners while still maintaining your own integrity.

Explanation:

A special promotion for its 20-ounce bottle of soda, a soft drink company printed a
message on the inside of each cap. Some of the caps said, "Please try again," while
others said, "You're a winner!" The company advertised the promotion with the
slogan "] in 6 wins a prize.
Suppose the company is telling the truth and that every 20-ounce bottle of soda it
fills has a 1-in-6 chance of being a winner. Seven friends each buy one 20-ounce
bottle of the soda at a local convenience store. Let X = the number who win a prize.

Answers

Using the principle of binomial probability, the probability that more than 3 friends win a prize is

Recall :

P(x = x) = nCx * p^x * q^(n-x)

Given the Parameters :

Probability of success, p = 1/6 q = 1 - p = 5/6 Number of trials, n = 7x3

Hence,

P(x ≥ 3) = p(x = 3) + p(x = 4) + p(x = 5) + p(x = 6) + p(x = 7)

P(x ≥ 3) = 0.0781 + 0.0156 + 0.0019 + 0.0001 + 0.000003

P(x ≥ 3) = 0.095703

Therefore, the probability that more than 3 friends win a prize is 0.0957

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