The following metabolic pathway involves the action of many enzymes within a cell.

Substrate 1 --> Substrate 2 --> Substrate 3 --> Product

Explain what would happen to the amount of product produced if the enzyme that acts on substrate 2 was not produced in the cell. All other enzymes at each step of the pathway are present.

Answers

Answer 1

Answer:

The metabolic pathway you described involves a series of chemical reactions that convert one substrate into the next substrate until the final product is formed. If the enzyme that acts on substrate 2 is not produced within the cell, the reaction that converts substrate 1 into substrate 2 would not occur. This would cause a block in the pathway, as substrate 2 would not be available for the enzyme that converts substrate 2 into substrate 3.

Explanation:

The metabolic pathway you described involves a series of chemical reactions that convert one substrate into the next substrate until the final product is formed. If the enzyme that acts on substrate 2 is not produced within the cell, the reaction that converts substrate 1 into substrate 2 would not occur. This would cause a block in the pathway, as substrate 2 would not be available for the enzyme that converts substrate 2 into substrate 3.

As a result, the amount of product produced would be severely decreased. Because of the missing enzyme, substrate 2 would not be converted into substrate 3, and subsequently, substrate 3 would not be converted into the final product. If this key enzyme is not present, the entire metabolic pathway would be halted at the step involving substrate 2, causing the cells to be unable to produce the final product and creating a bottleneck in the metabolic pathway.

It's important to remember that enzymes are catalysts, they speed up the reactions of the metabolic pathway and ensure the reactions occur at appropriate rates to support life, even a small change in the enzyme activity can affect the entire pathway and alter the final product quantity and quality.


Related Questions

which sentence is an example of a run-on sentence as a scared for birds and their winter he can help by feeding them

Answers

When two separate clauses are combined without the required punctuation or conjunctions, the phrase becomes run-on.

Food is scarce for birds in the winter you can help by feeding them.

Comma splicing and run-on sentences are mistakes that go hand in hand. While a comma splice happens when a comma is used to divide two distinct clauses, a run-on sentence happens when numerous independent clauses are not punctuated or connected in a single phrase.

Run on means to continue: continue. To continue (stuff in type) without a pause or a new paragraph: transitive verb run in. : To add or add anything to the conclusion of a paragraphed item, such as an entry from a dictionary.

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1.-5. Match the description to its anatomical term.

The system for gaseous exchange in the lungs

The system for maintaining a constant internal
environment in other tissues

The membranous sac that surrounds the heart

The wall that divides the heart into two cavities

Uppermost two chambers of the heart

a. Pericardium
b. Pulmonary circuit
c. Systemic circuit
d. Atria
e. Septum

Answers

a. Pericardiumb. Pulmonary circuitc. Systemic circuitd. Atriae. Septum

You and your sibling are trick-or-treating. Realizing

that your bag of Halloween candy is heavier, depends

on your____.

A) subliminal stimuli

B) perceptual set

C) size constancy

D) difference threshold

Answers

When playing trick-or-treating and then realizing that the bag of Halloween candy is heavier, it depends on your perceptual set.

Thus, the correct answer is B.

Subliminаl stimulаtion is sensory stimulаtion below а person's аbsolute threshold for conscious perception. Perceptuаl set is the tendency for perceptions to be influenced by one’s expectаtions or preconceptions. Perceptuаl constаncy is the tendency to perceive the size, shаpe, color, аnd brightness of аn object аs remаining the sаme even when the imаge it cаsts on the retinа chаnges. The difference threshold is the smаllest difference in stimulаtion needed to recognize thаt two stimuli аre different from eаch other 50% of the time.

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1. According to the video on Energy Flow Through Ecosystems, energy flows from the sun to the __________, then to the primary __________, then to the secondary ___________, then to the ___________ consumer, and then to the apex ____________, and finally to the ___________.

2. Green plants are the only __________ that make their own food using sunlight, water, carbon dioxide through a process called _______________.

3. When the plant makes its food the carbon dioxide is changed from gas to _________ and the gas called __________is produced.

The second video which explains the food chains and food webs will help with the following exercises.

4. A food _______ shows feeding relationships between animals that are in more than one food chain.

Below are some feeding relationships between animals in a woodland:

· Worms, voles, and mice eat vegetation.

· Badgers eat worms, voles and mice.

· Shrews and badgers eat worms.

· Barn owls eat shrews, voles and mice.

5. The animals in a food web that are in the food chains above would be:____________________________________________________.

6. In a trophic __________ of a food web, the plants are in level ______ and the highest level is the ______.

7. Organisms that feed on plants and animals are called __________.

Answers

1. Grass/ground 2.consumer 3.consumer 4.Tertiary 5. Predator

please help me, I'm from Vietnam you can translate

Answers

Answer:

What does it say? I can't read it well

Explanation:

Can we run out of renewable resources? Explain.

Answers

Answer:

No

Explanation:

Some resources will practically never run out. These are known as renewable resources. Renewable resources also produce clean energy, meaning less pollution and greenhouse gas emissions, which contribute to climate change.

Examples are Sun, Wind, and Water. We will always have sunlight and wind, right? So no, renewable resources CANNOT run out, hence the 'renewable' part. They come from sources that are not depleted when used. Others, like biomass, come from sources that can be replenished.

Hope this helps

Is Gause’s Principle accurate? Explain why or why not.

Answers

Yes, Gause’s Principle is accurate mainly due to his description of how two species with the same niche cannot coexist in the same habitat.

What is the application of Gause's principle?

Gause, which claims that it is impossible for two species to live when they are vying for the same resources. Gause's law is another name for this rule. A population will push out another population. If any of the members of the extinct population are still alive, it is because they have adapted to the new niche.

According to Gause's theory of competitive exclusion, two species that are vying for the same scarce resource cannot live in the same niche for an extended period of time.

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How do I put links in APA style? Pls tell me

Answers

Answer:

Explanation: Citing a Link in the Bibliography APA Style List the author's last name followed by first initial, separated by a comma. If there is more than one author, but less than six, put a comma directly after the first initial and list up to two more names in the same fashion. An "&" symbol should be used in place of a comma before the last name listed.

A young goat has downward-curved horns. Its father has upward-curved horns while its mother has downward-curved horns. Which of these statements is the explanation?

Answers

Statement 1 is the correct one because every individual receives one copy of the gene from their mother and one from their father.

The process by which a gene's information is used to create a functioning gene product, such as proteins or non-coding RNA, is known as gene expression. Transcription is the process through which the information in the gene is initially transformed into RNA.

And, then the information in the RNA will be translated into protein. This results in the synthesis of functional or non-functional proteins. For goat's horn, the protein keratin is required to buildup a tough structure.

Therefore, in the given situation, the gene combination regulates the shape of the horn of a young goat. Therefore, the correct statement is 1.

The complete question is -

A young goat has downward-curved horns. Its father has upward-curved horns while its mother has downward-curved horns. Which of these statements explains why the young goat has downward-curved horns?

1. The young goat inherited one copy of the gene for horn shape from its mother and one copy from its father. That gene combination instructs for proteins that connect in ways that make downward-curved horns.

2. The young goat inherited one copy of the gene for horn shape from its mother and one copy from its father. Those genes connect together to make its downward-curved horns.

3. The young goat inherited its copies of the gene for horn shape from its mother and not from its father. Just like its mother's genes, those genes instruct for proteins that connect in ways that make its downward-curved horns.

4. The young goat inherited its copies of the gene for horn shape from its mother and not from its father. Those genes connect together to make its downward-curved horns.

Which one is the answer?

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answer number 5 plsss
no nonsense

Answers

Any material of small granulometry, or up to five millimeters in size, is called sand. From that measure they are called stone. Stones are the result of the breakdown of rocks, just like sand, and in the crushing process it forms crushed stone.

How is sand formed?

The formation of sand begins with the action of wind, rain, sun, tree roots and microorganisms that wear down the rocks present in various regions of the continent. Over the years, pieces of the stones break loose and, little by little, turn into small grains. This process is called erosion.

What kind of rock is sand?

Sand is a detrital, mobile, permeable sedimentary rock that, according to the size of its grains, can be classified into coarse, medium and fine sand.

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What is the least common multiple of 72 and 96?

Answers

Answer:

288

Explanation:

Answer:288

Explanation:

Josie partially filled a graduated cylinder with water. she then dropped a rock into the water. the illustration below show what happened to the level of the water inside the graduated cylinder. what is the volume of the rock?

Answers

As the the illustration show volume of the rock is 5ml. The correct option is A.

What is volume?

The space occupied within an object's borders in three dimensions is referred to as its volume.

It is sometimes referred to as the object's capacity. Volume is the amount of space an object or substance occupies.

Volume, which is measured in cubic units, is the 3-dimensional space occupied by matter or encircled by a surface.

Since the graphic shows that 5 ml of water was displaced by the rock, we can infer that the rock's volume is 5 ml.

Thus, the correct option is A.

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Your question seems incomplete, the complete question is:

Josie partially filled a graduated cylinder with water. She then dropped a rock into the water. The illustration below shows what happened to the level of the water inside the graduated cylinder. What is the volume of the rock?

answer choices

5 mL

10 mL

35 mL

40 mL

What are two factors that increase the genetic variation in a population ?

Answers

Gene flow and genetic drift are two factors that increase the genetic variation in a population.

Genetic variations are the changes or alterations which can occur in the sequence of gene of the DNA. These genetic variations are very necessary as they enable different living beings to evolve and also survive. There are two factors which can cause an increase in the genetic variation of a particular population and they are gene flow and genetic drift.

Gene flow can be defined as the movement of genes which occurs in and out of a specific population.  The in-flow of genes in a population can help increase the genetic variation of the individuals that are a part of that  population. Genetic drift is defined as the change in allelic frequency of a  population which occurs by chance. It brings about genetic variation.

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the basic unit of all life. contains organelles the work together to maintain homeostasis within the organism.

Answers

Answer: the cell

Explanation:

A heterogenous group of yellow-brown pigments, often found in cardiac muscle and liver cells and in increasing amounts with age or debilitated states, is known as:

Answers

Answer:

Lipofuscin

Explanation:

Gonna take a guess and say these are Lipofuscin cuz these guys are also known as "age pigments" cuz they accumulate in large quantity as cells age.

Hope its right.

Base your answer on the information below and on your knowledge of biology.
A student measured oxygen and carbon dioxide concentration levels in an aquatic ecosystem during a 24 hour period. Identify two biological processes that are responsible for the production of varying amounts of carbon dioxide and oxygen within the aquatic ecosystem.

Answers

Two biological processes responsible for producing varying amounts of carbon dioxide and oxygen within aquatic ecosystems are 1) respiration by aquatic plants and animals and 2) photosynthesis by aquatic plants.

What is an aquatic ecosystem?

An aquatic ecosystem is any freshwater or saltwater environment and the characteristic flora, fauna (plants) and animals (animals) that inhabit that habitat. Freshwater ecosystems include rivers, lakes, and ponds. Saltwater ecosystems include seas and oceans. Aquatic ecosystems have historically been important to humans and other organisms. Aquatic ecosystems not only provide a food source for a wide variety of organisms, but are also essential for cycling important gases and nutrients such as carbon dioxide, nitrogen and phosphorus.

Aquatic ecosystems are known to have high levels of biodiversity.

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What specific host gene functions would you consider as strong candidates for such methylation by infecting viruses

Answers

Many viruses specifically methylate genes associated with the immune response, thus dampening that response and enhancing viral infectivity.

What are genes and what do they do?

A gene is the most fundamental physical and functional element of heredity. DNA is the building block of genes. Some genes serve as blueprints for the creation of proteins. Many genes, however, do not code for proteins. Genes in humans range in size from a few hundred DNA bases to over 2 million bases.

What are the four primary roles of genes?

Gene functions include:

Genes are genetic material components and consequently units of heredity.They have control over an individual's morphology or phenotype.Gene replication is required for cell division.Hereditary information is passed down through generations via genes.

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Full Question: What specific host gene functions would you consider as strong candidates for such methylation by infecting viruses?

Many viruses specifically methylate genes associated with the immune response, thus dampening that response and enhancing viral infectivity.

Many viruses specifically methylate protective genes, thus enhancing viral infectivity.

Many viruses specifically methylate genes associated with the cell cycle, thus activating DNA amplification and enhancing viral infectivity.

Many viruses specifically methylate genes associated with apoptosis, thus dampening that response and enhancing viral infectivity.

Which of the following best describes the
general pattern of biochemical evidence for
evolution?

There is no general pattern observed in
biochemical evidence for evolution.

If two species have more differences in DNA,
RNA, and proteins, they are more closely
related.

The more closely related two species are, the
fewer biochemical similarities in DNA, RNA,
and proteins they have.

The more closely related two species are, the
more biochemical similarities in DNA, RNA, and
proteins they have.

Answers

Based on the fact that certain enzymes and chemical processes are found in the cells of all or nearly all life on Earth.

What exactly is biochemical evolution?

The changes that occur at the molecular level in organisms throughout time are referred to as biochemical evolution (molecular evolution). These vary from single nucleotide deletions, additions, or substitutions to the rearrangement of gene sections to the duplication of whole genes or even complete genomes.

Carl Neuber, a German scientist, created the term “biochemistry” in 1903. However, research into this very living part of chemistry had begun much earlier. Claude Bernard has been awarded the Sirehood of Biochemistry. Anatomy, molecular biology, biogeography, fossils, and direct observation are all evidence for evolution.

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What is the process in prophase I that has caused genetic material exchange to take place?

Answers

Chromosome crossover is the mechanism by which homologous chromosomes couple up and exchange genetic material during prophase I.

Leptotene, zygotene, pachytene, diplotene, and diakinesis make up prophase I's five stages. Several significant activities, including as the pairing of homologous chromosomes and the reciprocal exchange of genetic material between these homologous chromosomes, take place during these stages in addition to those that take place in mitotic prophase. Prophase I progresses at varying rates according on sex and species.

Until ovulation, several species halt meiosis in the diplotene of prophase I. In humans, oocytes can be stopped in prophase I for decades before swiftly completing meiosis I just before ovulation.

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Please help! best answer gets brainliest

Answers

Answer:

help with what ? theres nothing there

Which of the following management practices attempts to minimize ecological impact by allowing some trees in a forest to grow to maturity

Answers

Getting unevenly aged stands through a selection process. Compared to even cutting, this uneven growth and trimming would boost biodiversity.

Tree stands that are uniform in age are all the same age. These trees are all of the same type and are planted at the same time. Therefore, setting up a biosphere reserve is the most efficient strategy to preserve a region's plant diversity. Ex-situ methods of conservation, such as seed banks, botanical gardens, and tissue culture, involve removing organisms from their natural habitat. By sucking carbon dioxide out of the atmosphere and storing it, forests aid in reducing the rate of climate change. Since the excess of carbon dioxide in the atmosphere is the main cause of climate change, this is a direct consequence.

The complete question is - Which management practices attempts to minimize ecological impact by allowing some trees in a forest to grow to maturity?

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Which of the following conclusions about the radiolabeled amino acid is best supported by the results of the experiment

Answers

It was largely integrated into proteins that control and oversee metabolic processes.

Amino acid molecules comprise proteins. Proteins and amino acids are the building blocks of life. After proteins have been digested or denatured, amino acids are still present. In order to maintain the body, the human body makes proteins from amino acids:

The body can produce energy from amino acids to digest food, grow, repair bodily tissue, and carry out a variety of other bodily functions.

Amino acids are divided into three groups:

Important amino acids

Unneeded amino acids

conditional amino acids

Amino acids are necessary for the synthesis of body protein as well as other essential nitrogen-containing compounds like creatine, peptide hormones, and certain neurotransmitters. Even though allowances are portrayed as meeting biological needs, amino acids.

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Neurons respond preferentially to the right eye or the left eye. This phenomenon is referred to as _____.
a. hemispheric specialization
b. bilateral dominance
c. retinotopic disparity
d. ocular dominance

Answers

Neurons preferentially react to either the right or left eye. This characteristic is known as ocular dominance.

Ocular dominance, also known as dominant eye, occurs when one eye is used more than the other, when one eye has greater vision, or when one eye has stronger focus. Determining which eye is dominant might be useful for tasks that demand concentration on a goal. Baseball is one of these activities.

Ocular dominance, also known as eye preference or eye condition, is the proclivity to favor visual information from one eye over the other. This is analogous to right-handed or left-handed laterality. The dominant eye side and dominant hand side, on the other hand, do not always correspond. Identifying your dominant eye is essential while participating in activities like baseball, shooting range, or golf. Photographers can also improve their images by using their dominant eye. Shooters can better aim their targets using their dominant eye.

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When describing DNA replication we say that DNA polymerase synthesizes the new strand in a 5' to 3' direction, moving down the template strand from 3' to 5'. Briefly explain why replication always proceeds in this direction

Answers

DNA replication occurs in a 5' to 3' direction because the enzymes used for replication, known as DNA polymerases, can only add nucleotides to the 3' end of an existing strand of DNA.

This is because the 3' end has an exposed hydroxyl (-OH) group which can be used to add to the growing strand of nucleotides. As such, the polymerase moves down the template strand from 3' to 5', adding new nucleotides in the 5' to 3' direction.

This ensures that the newly synthesised strand is complementary to the template strand, as newly added nucleotides are added in the same direction as the original strand.

Additionally, this directional synthesis also means that both strands of the DNA double helix can be synthesised simultaneously, with each strand serving as the template for the other. This ensures that the complete DNA molecule is correctly replicated in the same manner as the original strand.

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It is easier to carry out a controlled experiment in the field than it is in the laboratory. True or false

Answers

Answer:

true

Explanation:

A researcher discovers a mysterious unknown multicellular eukaryotic organism. She would be confident that it is an animal if she observed that it ____

Answers

A researcher discovers a mysterious unknown multicellular eukaryotic organism. She would be confident that it is an animal if she observed that it has specialized organs, such as eyes, ears, or a heart, or if it moved in response to its environment.

Animals are a distinct group of multicellular eukaryotes, and they are characterized by the presence of specialized organs that aid in the collection of energy and nutrients, as well as providing a means for locomotion. These organs can be as simple as a single cell like the cilium on a paramecium, or as complex as the human brain. Additionally, animals usually respond to their environment in some way, such as locomotion or behavioral responses.

The researcher's observation of specialized organs and movement in response to its environment would be a strong indication that the organism is an animal. By looking at the size, shape, and organization of the cells under a microscope, the researcher could further confirm the identity of the organism. For instance, the presence of cilia or flagella would suggest that the organism is a protozoan, while the presence of an organized nervous system could indicate that it is a more complex organism, such as an arthropod or a vertebrate.

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Which of the following statements characterized meiosis 1?

Answers

The statements that characterize meiosis I are:

B) The chromosome number remains the same from n to n.

C) Homologous chromosomes line up at the cell equator.

E) The chromosome number is reduced from 2n to n.

F) Each chromosome consists of two sister chromatids.

H) Crossing over can occur during synapsis.

What is the meiosis  stage about?

Meiosis I is the first of two cell division events that occur during meiosis, a type of cell division that produces gametes (sex cells). Meiosis I is characterized by several key events, such as:

Homologous chromosomes line up at the cell equator: During meiosis I, homologous chromosomes (pairs of chromosomes that are similar in shape and size and carry genes for the same traits) line up and pair with one another at the cell equator. This process, called synapsis, allows for the exchange of genetic material between the chromosomes through a process called crossing over.

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See full question below

Which of the following statements characterize meiosis I? Select all that apply.

Multiple select question.

A)Four nuclei start to form around the chromosomes.

B)The chromosome number remains the same from n to n.

C)Homologous chromosomes line up at the cell equator.

D)Sister chromatids are pulled apart at the centromeres.

E)The chromosome number is reduced from 2n to n.

F)Each chromosome consists of two sister chromatids.

G)Sister chromatids line up at the cell equator.

H)Crossing over can occur during synapsis.

I need help with this. The topic is renewable and non renewable resources

Answers

Plastic packaging has non-renewable resources, whereas paper packaging is renewable. The difference between renewable and non-renewable energy sources is that renewables use resources that are not depleted or regenerated in nature.

What do you understand by non-renewable resources?

Non-renewable sources are those that have a limited reserve on our planet and that do not regenerate - or that take thousands of years to do so. Oil is perhaps the best known example, are ores and natural gas.

The difference between renewable and non-renewable energy sources is that renewables use resources that are not depleted or regenerated in nature. Non-renewable energy sources, on the other hand, use resources that are depleted in nature and, therefore, can generate several problems for the environment.

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If someone engages in a short, intense burst of activity lasting less than 30 seconds, which energy system will contribute the most to ATP production

Answers

The phosphagen energy system will contribute the most to ATP production during a short, intense burst of activity lasting less than 30 seconds. This energy system utilizes ATP and phosphocreatine to provide energy for activities that require an immediate burst of energy.

The phosphagen energy system is a vital component of energy production during short, intense bursts of activity lasting less than 30 seconds. This energy system is responsible for providing energy for activities that require an immediate burst of energy. The main source of energy used in this system is the ATP and phosphocreatine stored in the muscle cells.

When the body is put under an intense physical demand, the phosphagen energy system is activated. This system works quickly and efficiently to produce ATP, the energy currency of the body. ATP is produced through a process called phosphorylation, where a phosphate molecule is added to ADP. The body uses ATP for a variety of biochemical processes, including muscle contraction.

The phosphagen energy system is the most efficient at providing energy for short-term, intense physical activity. It is able to quickly and efficiently produce enough ATP to meet the body’s energy demands. The phosphagen system is also able to replenish ATP stores in the muscle cells more quickly than other energy systems. This makes it ideal for activities such as sprinting and weightlifting, which require an immediate burst of energy.

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Which phylogenetic tree highlights the most recent common ancestor of all animals with four limbs (where limbs include legs, arms, and wings)

Answers

It draws attention to the taxon, or most recent common ancestor, of all tetrapods. The tips and nodes of the tree, respectively, represent groups of descendant taxa and common ancestors of descendants.

The evolutionary connections of biological species are described by the phylogenetic tree, often called phylogeny. The branching pattern of the phylogenetic tree illustrates how a series of shared ancestors gave rise to diverse species or groupings.

The phylogenetic tree helps us understand a person's complete life history or life.

Follow each taxon's lineage back in time (toward the base of the tree) until all the lineages meet to identify the most recent common ancestor of a group of taxa. Their most recent shared ancestor is represented by that node.

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What kind of connection does the author draw between working conditions and profits Read the scenario below and answer the question that follows. Mr. Willis separates his students into four teams that each represent four different perspectives on a social issue. Each group is to establish an argument supporting why their perspective is correct and then present the information to the class. After each group presents their perspective, Mr. Willis guides the class through a period of analyzing and questioning each perspective. Which of the following types of collaborative learning approaches has Mr. Willis utilized To install the vinyl liner, it costs $1.95 per square foot. You have $1000 in your budget to spend on the liner installation. What is the largest pool you can get without going over your liner budget Review the paragraph that begins in themiddle of page 3 and continues to page 4.How does the discussion of nursery rhymesMAINLY support the author's claims?A- It helps to illustrate common characteristics ofsuccessful slogans.B- It stresses the importance of using child-friendlylanguage in slogans.C- It outlines the criteria historians use to analyzeslogans.D- It identifies a common source of easily-recognizedmaterial for successful slogans. Which sentence below correctly uses theinfinitive to see?A. Unfortunately, we were not able to, because of theclouds, see the planets in conjunction.B. We have a chance to, because I bought tickets, see thenew movie that was just released.C. At the soccer event we were able to, because of thesparse crowds, see the entire field.D. Because of the way the sun shone through the rain, wewere able to see a double rainbow. Please help me find x and y. 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Her features taken collectively indicated great determination and will power.As she came forward to welcome me in her long and full flowing white dress (the interview took place in the summer), surmounted by two large globe sleeves which were fashionable at the time and which lent her an exaggerated appearance, I remember most vividly I was no less puzzled than stunned. I actually trembled all over with fear at her imposing proportionshaving never in my life seen such a peculiar and odd fashion. I clung to my father in fear. Her kindly expression and sympathetic smiles found little appreciative response at the outset, as I stood half dazed at her personality and my new environment. For really, a new world had dawned on me. After a time, when my homesickness was over and the novelty of my surroundings began gradually to wear away, she completely won me over through her kindness and sympathy. I began to look upon her more like a mother. She seemed to take a special interest in me; I suppose, because I was young and helpless, and away from my parents, besides being the youngest pupil in the school. She kept me among her girl pupils and did not allow me to mingle with what few boys there were at the time.Select the sentence that best identifies the purpose of the excerpt. To express the narrators happiness about starting school in a new place. To persuade the reader to adopt the narrators perspective about his dislike of his parents. To entertain the reader with a funny anecdote about his first day of school. To inform the reader how the narrator felt when meeting Mrs. Gutzlaff, and to characterize his teacher that had a great impact on him. Write 6789 correct to 3 significant figures How did the US Lend-Lease Program of 1939 help the Allies it gave them war supplies? Why was Sinners in the Hands of an Angry God popular? 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